The probability of revision sinus surgery including the removal of nasal polyps is higher if the patient has asthma or is on antibiotics at the time of their initial surgery. However, higher age was not a predictor of revision surgery, according to a new study.
A carnation-like nanostructure could someday be used in bandages to promote wound healing. Researchers report that laboratory tests of their nanoflower-coated dressings demonstrate antibiotic, anti-inflammatory and biocompatible properties. They say these results show these tannic acid and copper(II) phosphate sprouted nanoflower bandages are promising candidates for treating infections and inflammatory conditions.
Researchers have developed a revolutionary injectable granular filler that could transform the way diabetic wounds are treated, potentially improving patient outcomes. The groundbreaking study introduced an innovative approach about using specialized porous dermal fillers that accelerate tissue healing and regeneration.
A small molecular strand could hold the key to solving one of the greatest global health challenges. When bacteria develop resistance to antibiotics, it can be deadly, but researchers have now decoded part of the bacteria's defence mechanism.
A new study has identified an RNA molecule that is important for skin wound healing. The research may have implications for the treatment of hard-to-heal wounds.
It's almost time to dust off the Halloween decorations and adorn the house with all manner of spooky things, including the classic polyester spider webs. Scientists have made their own version of fake spider silk, but this one consists of proteins and heals wounds instead of haunting hallways. The artificial silk is strong enough to be woven into bandages that helped treat joint injuries and skin lesions in mice.
In an infection, there are tens of thousands of peptides that provide a wealth of information about which bacteria have caused the infection and how severe it is. A research team combined clinical questions with mathematical methods to systematically analyze these peptides. This has the potential to transform the diagnosis and treatment of infections in the future.
New research suggests there may be a more effective method to detect bacteria during wound debridement.
Radiation is a powerful tool for treating cancer, but prolonged exposure can damage the skin. Radiation-induced skin injuries are painful and increase a person's chances of infection and long-term inflammation. Now, researchers report an aspirin-containing hydrogel that mimics the nutrient-rich fluid between cells and accelerates healing of skin damaged by radiation in animals. With further development, the new salve could provide effective and rapid wound healing for humans.
Researchers have developed an inexpensive bandage that uses an electric field to promote healing in chronic wounds. In animal testing, wounds that were treated with these electric bandages healed 30% faster than wounds treated with conventional bandages.
New research shows that a certain bug, Alcaligenes faecalis (A. faecalis), can facilitate healing of hard-to-treat wounds among people with diabetes. While there are many studies done on potentially harmful bacteria in wounds, the researchers discovered that A. faecalis, a bacterium found in many types of chronic wounds, actually boosts healing of diabetic wounds. The researchers found that the beneficial bacterium can promote skin cell movements that are essential for wound closure by inhibiting enzymes that are over-produced in people with diabetes.
A new study shows that analyzing nasal microbiota outperforms gut microbiota analysis to predict sepsis in the ICU.
Researchers have designed a regenerative medicine therapy to speed up diabetic wound repair. Using tiny fat particles loaded with genetic instructions to calm down inflammation, the treatment was shown to target problem-causing cells and reduce swelling and harmful molecules in mouse models of damaged skin.
Researchers are on a mission to kill drug-resistant bacteria, and a new study has identified a therapy that can penetrate the slime that such infections use to protect themselves from antibiotics.Researchers have shown that an antimicrobial peptide from cows has potential for treating incurable infections from the bacterium Klebsiella pneumoniae. The bacteria, commonly found in the intestines, is usually harmless. It becomes a health hazard when it enters other parts of the body and can cause pneumonia, urinary tract and wound infections. Those at highest risk include seniors and patients with other health problems such as diabetes, cancer, kidney failure and liver disease.
Many surgeons remove the bursa when repairing rotator cuff injuries, but a new animal study suggests that the small tissue helps with healing.
Polymer-based hydrogels are used to treat skin ailments and in tissue engineering because of their ability to retain water, deliver drugs into wounds, and biodegrade. However, they are complicated to manufacture and not very resilient to external forces like rubbing against clothing, sheets, or wound dressings. Scientists have now created a hydrogel enhanced with the amino acid polylysine and blood plasma that is easier to synthesize, contains natural antibiotic properties, and promotes cell growth.
Scientists have uncovered a key step in the wound healing process that becomes disabled in diseases like diabetes and aging, contributing to a global healthcare cost of managing poorly healing wounds exceeding $250 billion a year. Importantly, the research reveals a molecule involved in the healing of tissues that -- when injected into animal models -- leads to a drastic acceleration of wound closure, up to 2.5 times faster, and 1.6 times more muscle regeneration.
A cross-disciplinary team has developed a new contact lens material that could act as a bandage for corneal wounds while releasing drugs in a controlled manner to help the eye heal faster.
An effective treatment for chronic wounds that does not involve antibiotics, but an ionised gas to activate a wound dressing, has been developed by a team of international scientists.
The new GastroShield gel can be sprayed through an endoscope after polyps are removed during colonoscopy, protecting the gut and helping prevent complications from weakened gastrointestinal tissues.
Medical researchers have found a peptide which, when administered intravenously, homes in on the new blood vessels that are forming in damaged tissue. The peptide has been used as a delivery vehicle for therapeutics targeted at regenerating tissues. A new study has discovered that the peptide activates the natural healing mechanism in the tissue, accelerating regeneration. The finding opens new opportunities to treat not only skin wounds, but also any injuries resulting from accidents and traumas, such as ruptured muscles and fractured bones.
Researchers have identified a new way to harness the antioxidant and antibacterial properties of a botanical compound to make nanofiber-coated cotton bandages that fight infection and help wounds heal more quickly.
New findings report that a class of small RNAs (microRNAs), microRNA-29, can restore normal skin structure rather than producing a wound closure by a connective tissue (scar). Any improvement of normal skin repair would benefit many patients affected by large-area or deep wounds prone to dysfunctional scarring.
Nearly every organism on Earth follows a natural circadian rhythm that is coded by your cell's clock genes, which do exactly as you suspect from the name: regulate your body's rhythm on a 24-hour basis. Most cells in mammalian bodies have cilia of some sort, which are hair-like structures that perform a variety of functions such as movement for motile cilia and aiding in structure in function for non-motile, or primary, cilia. The primary cilia also act as a sensory organ for the cell, a function which has illuminated the primary cilia's potential role in the healing process and how bodies heal at a different rate according to our circadian rhythm. In this research, the role of the primary cilia, biological clock and wound healing is explored.
Hydrogels have demonstrated promise for effectively treating skin wounds. However, currently available hydrogels adhere to the skin and swell when absorbing fluid discharge, causing the wound site to expand during the initial stages of recovery. Now, researchers have developed a novel type of hydrogel using a biocompatible substance found in seaweed. This hydrogel results in lower adhesion and swelling, but provides a high therapeutic effect, promising recovery without wound expansion.
A team of researchers has engineered an innovative magnetic wound-healing gel that promises to heal diabetic wounds three times faster, reduce the rates of recurrence, and in turn, lower the incidents of limb amputations. The innovative magnetic hydrogel, which contains skin cells for healing as well as magnetic particles, takes a comprehensive 'all-in-one' approach to wound healing, accelerating the process on several fronts. To maximize therapeutic results, a wireless external magnetic device is used to activate skin cells and accelerate the wound healing process.
A research article presents a significant breakthrough in the area of skin regeneration and wound healing.
Researchers have invented a nano-thin superbug-slaying material that could one day be integrated into wound dressings and implants to prevent or heal bacterial infections. The innovation -- which has undergone advanced pre-clinical trials -- is effective against a broad range of drug-resistant bacterial cells, including 'golden staph', which are commonly referred to as superbugs.
A recent study has introduced a groundbreaking milestone in tissue regeneration by developing a technology that utilizes autologous blood to produce three-dimensional microvascular implants.
Bandages infused with casein, a protein that occurs naturally in cow's milk, significantly improved wound healing in rats compared to those in control groups, according to a new study by researchers.
Investigators have provided new understanding of how diabetes delays wound healing in the eye, identifying for the first time two related disease-associated changes to the cornea.
The mixture of honey and vinegar, also known as oxymel, has been used as a medical treatment throughout history and now scientists have established that this combination could have modern applications in the treatment of wounds.
Scientists have invented a paper-like, battery-free, AI-enabled sensor patch -- PETAL -- for convenient and effective monitoring of wound recovery. This novel technology provides early warning of complications to improve wound care. The paper-like, battery-free PETAL sensor patch uses five colorimetric sensors to measure biomarkers in the wound within 15 mins. A proprietary AI algorithm quickly analyses the digital image of the sensor patch to determine wound healing status with an accuracy rate of 97%.
To ensure that wounds remain tightly sealed in the abdomen after surgery, researchers have developed a patch with a sensor function. The polymer patch warns before the occurrence of dangerous leaks on sutures in the gastrointestinal tract take hold, while closes the areas on its own. A new material now enables a fast, easy and non-invasive leak diagnosis.
The body is pretty good at healing itself, though more severe wounds can require bandages or stitches. But researchers have now developed a wound-healing ink that can actively encourage the body to heal by exposing the cut to immune-system vesicles. The ink can be spread into a cut of any shape using a 3D-printing pen, and in mice, the technology nearly completely repaired wounds in just 12 days.
Complicated, hard-to-heal wounds are a growing medical problem and there are currently only two drugs approved with proven efficacy. In a new study on humans, researchers show that treatment with a specific type of modified lactic acid bacteria works well and has a positive effect on the healing of wounds.
Using a new strategy, researchers were able to reduce the challenging MRSA infection in the wounds of diabetic mice by 94%. They were able to completely sterilize the wounds in several of the mice, and the rest had significantly reduced bacterial burden.
Engineers have designed tissue-derived 'smart' sutures that can not only hold tissue in place, but also detect inflammation and release drugs. The sutures are coated with hydrogels that can be embedded with sensors, drugs, or cells that release therapeutic molecules.
The study is the first to identify a damage response pathway that is distinct from but parallel to the classical pathway triggered by pathogens.
A nanocellulose wound dressing that can reveal early signs of infection without interfering with the healing process has been developed.
Chronic wounds are a major health problem for diabetic patients and the elderly -- in extreme cases they can even lead to amputation. Using electric stimulation, researchers have developed a method that speeds up the healing process, making wounds heal three times faster.
Young babies and newborn mice can naturally heal damage to the bones that form the top of the skull, but this ability is lost in adults. Researchers developed a novel approach that promoted bone regeneration in mice without implantation of bone tissue or biomaterials.
The fruit of the cocklebur plant, which grows worldwide and is often considered a noxious weed, has antioxidant and anti-inflammatory components that could make it useful as a skin protectant, according to new research.
Scientists have employed inventive chemistry to produce an injectable biomaterial with significantly improved adhesive strength, stretchability, and toughness. This chemically modified, gelatin-based hydrogel had attractive features, including rapid gelation at room temperature and tunable levels of adhesion. This custom-engineered biomaterial is ideal as a surgical wound sealant, with its controllable adhesion and injectability and its superior adherence to a variety of tissue and organ surfaces.
Researchers create a biomimetic model to study wound healing in burn and laceration wounds. The team designed an in vitro model system made of fibroblasts embedded in a collagen hydrogel. Wounds were created in this microtissue using a microdissection knife to mimic laceration or a high-energy laser to simulate a burn. They discovered that fibroblasts clear away damaged tissue before depositing new material. This part of the healing process is slower in burn wounds.
Researchers have developed a small, flexible, stretchable bandage that accelerates healing by delivering electrotherapy directly to the wound site. The bandage also actively monitors the healing process and then harmlessly dissolves -- electrodes and all -- into the body after it is no longer needed.
A new antimicrobial suture material that glows in medical imaging could provide a promising alternative for mesh implants and internal stitches.
The World Health Organization (WHO) ranks antibiotic resistance as one of the top ten threats to global health. There is therefore a great need for new solutions to tackle resistant bacteria and reduce the use of antibiotics. A group of researchers are now presenting a new spray that can kill even antibiotic-resistant bacteria, and that can be used for wound care and directly on implants and other medical devices.
Researchers develop an injectable hydrogel that treats infections around prosthetics without the problems caused by current treatments. The black phosphorus-enhanced gel has a porous structure, excellent injectability, and rapid self-healing properties. Tests show it has good stability and low toxicity to tissue cells, and irradiating the gel with near infrared light causes it to release silver ions. This process was highly efficient at inhibiting S. aureus, common bacteria that cause disease in humans.
Scientists have discovered a new material that can be applied to diabetic wounds to heal them faster with just one application.
Patients with advanced ankle osteoarthritis who undergo surgery see equally good outcomes from the two main surgical treatments for osteoarthritis, a new study has shown.
A thermal-imaging tool to screen for chronic wounds could enable nurses to identify these hard-to-heal sores during the first assessment at a person's home. Nearly half a million Australians live with chronic wounds, which greatly affect their quality of life and cost the nation's health system around $3 billion each year.
Researchers at Indiana University School of Medicine are looking for ways to heal wounds by using a healing protein that is active in fetuses, but largely inactive in adults and absent in diabetic adults.
Surgical care experts have today unveiled two studies that will help to provide safer surgery for thousands of patients around the world -- particularly in Low- and Middle-income Countries (LMIC).
A new study compares the effectiveness of two antisepsis aqueous solutions in reducing the risk of infection in patients requiring surgery for open fractures. The research team found that contrary to current international recommendations, chlorhexidine gluconate was not superior to povidone-iodine in an alcohol or aqueous solution in preventing surgical site infection. The results suggest health care practitioners can select either aqueous-based antisepsis solution when treating open fractures on the basis of solution availability, patient contraindications, or product cost.
Every year around 2 million people die worldwide from hemorrhaging or blood loss. Uncontrolled hemorrhaging accounts for more than 30% of trauma deaths. To stop the bleeding, doctors often apply pressure to the wound and seal the site with medical glue. But what happens when applying pressure is difficult or could make things worse? Or the surface of the wound is too bloody for glue? Drawing inspiration from nature, researchers have developed a medical adhesive that could save lives, modeled after structures found in marine animals like mussels and flatworms.
Even months after critical illness for sepsis, children are at risk for new or worsening medical conditions, a study suggests.
Researchers recently published study results showing that administering immunotherapy drug pembrolizumab before surgery for oral cavity cancer did not increase rates of complication during and after surgery.
A single chemical is key to controlling when hair follicle cells divide, and when they die. This discovery could not only treat baldness, but ultimately speed wound healing because follicles are a source of stem cells.
New research demonstrates that tissue nanotransfection can serve as a non-viral, topical, gene-editing delivery device.
A diet of fruits and vegetables, whole grains, low-fat dairy foods and lean meats, low in salt and sugar, is associated with reduced psoriasis severity, new research finds.
Researchers have achieved a breakthrough in wearable health technology by developing a novel self-healing electronic skin (E-Skin) that repairs itself in seconds after damage. This could potentially transform the landscape of personal health monitoring.
Psoriasis is a chronic skin disease that manifests itself mainly with skin symptoms (dryness, itching, scaly skin, abnormal patches and plaques). It affects about 2% of the population and is mediated by an altered immune system response that triggers the proliferation of skin cells. Depending on the severity, there are different therapeutic options (topical medications, phototherapy, systemic drugs, etc.), but some conventional treatments can have harmful effects on patients.
In a new study, researchers have determined that a protein called NF-kB c-Rel can intensify the symptoms of psoriasis when activated by signals from the body's immune system. Understanding how 'c-Rel' affects skin inflammation could lead to new treatments.
Your parents were right: Scratching an itchy rash really does make it worse. Now we know why, thanks to new research that uncovers how scratching aggravates inflammation and swelling in a mouse model of a type of eczema called allergic contact dermatitis.
Zika virus hijacks the skin of its human host to send out chemical signals that lure more mosquitoes to infect and spread the disease further, new research shows.
Systemic lupus erythematosus commonly presents as a rash. The rashes are caused by inflammation from the immune system fighting the body.
A natural compound derived from gut-friendly bacteria significantly slows the progression of vitiligo and may restore pigmentation, reports a new pre-clinical study in mice.
Basal cell carcinomas, the most common form of skin cancer, occur in chronically sun-exposed areas such as the face. Locally advanced tumors in particular can be difficult to treat surgically. A research team has now investigated the effectiveness of a new type of therapy and achieved promising results: The active substance TVEC led to a reduction in the size of the basal cell carcinoma in all study participants, which not only improved surgical removal, but also led to a complete regression of the tumor in some of the patients.
People with the skin condition psoriasis often have invisible inflammation in the small intestine with an increased propensity for 'leaky gut', according to new research. These changes in the gut could explain why psoriasis sufferers often have gastrointestinal problems and are more prone to developing Crohn's disease.
Sunburn has traditionally been attributed to UV-induced DNA damage. However, a new study reveals that RNA, another vital cellular molecule, plays a major role in triggering acute sunburn reactions.
Painful skin and trouble sleeping are among the problems reported when tapering cortisone cream for atopic eczema, according to a new study. Many users consider the problems to be caused by cortisone dependence.
A new study uncovers how a novel immunotherapy prevents squamous cell carcinoma, with benefits lasting five years after treatment. This therapy is the first to activate specific components of the adaptive immune system, particularly CD4+ T helper cells, which are not known to be involved in traditional cancer treatments. This work highlights the potential for similar immunotherapies to prevent other cancers throughout the body.
Researchers have traced a cellular route Ebola virus (EBOV) uses to traverse the inner and outer layers of skin and emerge onto the skin's surface. The study identifies new cell types within the skin that are targeted by EBOV during infection and shows that human skin specimens actively support EBOV infection. Overall, the findings, suggest that the skin's surface may be one route of person-to-person transmission.
Wearing sunscreen is important to protect your skin from the harmful effects of UV radiation but doesn't cool people off. However, a new formula protects against both UV light and heat from the sun using radiative cooling. The prototype sunblock kept human skin up to 11 degrees Fahrenheit (6 degrees Celsius) cooler than bare skin, or around 6 degrees Fahrenheit (3 degrees Celsius) cooler than existing sunscreens.
Researchers created realistic, skin-like replicas made of Ecoflex, a type of silicone rubber that can potentially serve as a platform to evaluate risks of bacterial infections from intravenous catheters and test wearable sensors, among other biomedical applications.
A new approach to treat rosacea and other inflammatory skin conditions could be on the horizon, according to a new study.
Researchers have created a novel protein-based gel as a potential ingredient in sustainable and high-performance personal skincare products (PSCPs). This protein-based material, named Q5, could transform the rheological -- or flow-related -- properties of PSCPs, making them more stable under the slightly acidic conditions of human skin. This innovation could also streamline the creation of more eco-friendly skincare products, offering increased efficacy and durability while addressing market demands for ethically sourced ingredients.
Researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor development in skin cancer.
Hidradenitis suppurativa (HS) is an immune disease that affects up to 4% of the global population and causes painful, recurring skin lesions and inflammation, primarily in the folds of the skin. It commonly affects women of African American descent.
The skin microbiome plays a key role in skin health and disease. While imbalances in skin microbiome composition are linked to disease, studying it has been challenging due to limited methods for culturing multiple bacterial species together. Now, scientists have developed a new medium which allows co-culturing of key skin bacteria while preserving their natural balance, opening new pathways for studying microbial interactions and skin health.
A study provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory roles in the tumor environment. The results are relevant for the development of novel skin cancer therapies, particularly in the field of immunotherapy.
The mechanisms underlying skin renewal are still poorly understood. Interleukin-38 (IL-38), a protein involved in regulating inflammatory responses, could be a game changer. A team has observed it for the first time in the form of condensates in keratinocytes, the cells of the epidermis. The presence of IL-38 in these aggregates is enhanced close to the skin's surface exposed to atmospheric oxygen. This process could be linked to the initiation of programmed keratinocyte death, a natural process in the epidermis. This study could bring new perspectives for the study of human epidermis and the illnesses that affect it.
Collecting images of suspicious-looking skin growths and sending them off-site for specialists to analyze is as accurate in identifying skin cancers as having a dermatologist examine them in person, a new study shows.
Researchers have developed a patch for easier and more effective treatment of psoriasis. The method may also be used in treatment of other inflammatory skin diseases.
New collaborative research has shown that using a fan in hot and humid weather reduces cardiac strain in older people, contradicting recommendations from the Centers of Disease Control and Prevention in the US. The study looked at the efficacy of different low-cost cooling strategies -- such as electric fans with and without spraying water on the skin -- for older adults, who are known to be at a heightened health risk during hot summer weather.
A team led by researchers has discovered that a group of cells located in the skin and other areas of the body, called neural crest stem cells, are the source of reprogrammed neurons found by other researchers. Their findings refute the popular theory in cellular reprogramming that any developed cell can be induced to switch its identity to a completely unrelated cell type through the infusion of transcription factors.
Researchers have developed a revolutionary injectable granular filler that could transform the way diabetic wounds are treated, potentially improving patient outcomes. The groundbreaking study introduced an innovative approach about using specialized porous dermal fillers that accelerate tissue healing and regeneration.
A research team has developed a deep skin-stimulating LED mask which has been verified in clinical trials to improve dermis elasticity by 340%.
Thin, stretchy skin -- like that of a pig or human -- significantly lessens the underlying damage that occurs when it's punctured. Pig skin even outperforms synthetic materials that are designed to mimic skin, a new study finds. Its special qualities, in particular its ability to dissipate the energy of a puncturing object, greatly reduce the damage to deeper tissues, researchers report.
Using a few zaps of electricity to the skin, researchers can stop bacterial infections without using any drugs. For the first time, researchers designed a skin patch that uses imperceptible electric currents to control microbes.
Scientists developed a way of using artificial intelligence to check for skin cancer with the AI tool, which was trained on data from 53,601 skin lesions from 25,105 patients, outperforming existing methods in a new study.
Prenatal human skin atlas and organoid will accelerate research into congenital diseases and lead to clinical applications for regenerative medicine.
Skin pigmentation may act as a 'sponge' for some medications, potentially influencing the speed with which active drugs reach their intended targets, a pair of scientists report.
A new study has identified an RNA molecule that is important for skin wound healing. The research may have implications for the treatment of hard-to-heal wounds.
Scientists believe the hormone hepcidin, when produced in the skin, may be the root cause of psoriasis -- a chronic and sometimes debilitating skin disease that affects 2-3% of the global population.
It's almost time to dust off the Halloween decorations and adorn the house with all manner of spooky things, including the classic polyester spider webs. Scientists have made their own version of fake spider silk, but this one consists of proteins and heals wounds instead of haunting hallways. The artificial silk is strong enough to be woven into bandages that helped treat joint injuries and skin lesions in mice.
A research team has successfully recreated the structure of wrinkles in biological tissue in vitro, uncovering the mechanisms behind their formation.
Using cutting-edge bioinformatics techniques for gene identification and sequencing, researchers are comprehensively mapping signaling pathway distributions in both normal and acne-affected skin.
A team has uncovered clues to the mechanism behind vitiligo, a skin pigmentation disorder said to have a worldwide incidence of 1-2%.
A new study shows that skin fungus colonization of Malassezia globosa speeds up breast cancer tumor growth.
There are some pretty strange ingredients in cosmetics and skin care products. One example is snail mucin -- also known as snail slime -- which is used for its moisturizing and antioxidant properties. But researchers might have found something even weirder to put on your face: molecules made by fish gut bacteria. In cultured cells, the compounds had skin-brightening and anti-wrinkle properties, making them potential ingredients for your future skin care routine.
Childhood obesity can contribute to the development of common immune-mediated skin diseases (IMSDs), such as alopecia areata, atopic dermatitis, and psoriasis, new research finds. Maintaining a healthy weight could potentially help lower the chances of developing these skin conditions. A novel study details the findings of an analysis of 2,161,900 Korean children from 2009 to 2020 to investigate the relationship between obesity or dynamic changes in body weight and the development of IMSDs.
The health benefits of sunshine could outweigh the risks for people living in places with limited sunlight, such as parts of the UK, a study suggests. Exposure to higher levels of ultraviolet (UV) radiation in areas with low sunlight was linked to a drop in deaths from cardiovascular disease and cancer, according to the research.
An unprecedented study reveals strategy to decrease the burden of alopecia areata, atopic dermatitis, psoriasis and other autoimmune conditions.
Radiation is a powerful tool for treating cancer, but prolonged exposure can damage the skin. Radiation-induced skin injuries are painful and increase a person's chances of infection and long-term inflammation. Now, researchers report an aspirin-containing hydrogel that mimics the nutrient-rich fluid between cells and accelerates healing of skin damaged by radiation in animals. With further development, the new salve could provide effective and rapid wound healing for humans.
Babies born very early had stronger neurodevelopmental performance at 1 year if they received more skin-to-skin care as newborns, a study found.
A genetic diagnostic method using a small sample of skin from the upper arm could identify rare neurodevelopmental disorders in a non-invasive way, according to researchers.
Changes in gene expression in sebaceous glands have now been spatially mapped. The study documents at high resolution changes in gene expression in the course of sebum synthesis and identifies new candidates for the modulation of sebum production.
Hair follicle infections are often difficult to treat because bacteria settle in the gap between hair and skin, where it is difficult for active substances to reach them. In order to investigate this scenario more closely in the laboratory, researchers have now developed a model with human hair follicles embedded in a matrix produced using 3D printing. In the future, this model can be used to test the effectiveness of new drug candidates against corresponding pathogens directly on human follicles.
New research shows that a certain bug, Alcaligenes faecalis (A. faecalis), can facilitate healing of hard-to-treat wounds among people with diabetes. While there are many studies done on potentially harmful bacteria in wounds, the researchers discovered that A. faecalis, a bacterium found in many types of chronic wounds, actually boosts healing of diabetic wounds. The researchers found that the beneficial bacterium can promote skin cell movements that are essential for wound closure by inhibiting enzymes that are over-produced in people with diabetes.
A study of 17 commonly used synthetic 'forever chemicals' has shown that these toxic substances can readily be absorbed through human skin.
An international research team has discovered a new way to effectively treat cancer, by using nutrients to reactivate suppressed metabolic pathways in cancer cells.
Researchers have designed a new genetic therapy that could alleviate debilitating giant moles in a rare skin condition.
Engineers have created a patch that combines sensors and bacteria to interact with the body.
Researchers have successfully treated the skin diseases epidermolytic ichthyosis and ichthyosis with confetti by transplanting genetically healthy skin to inflamed areas. Their work could pave the way for a new and effective treatment strategy for these skin disorders.
Researchers are developing a new therapeutic approach that uses nanoparticles for the treatment of skin and lung fibrosis, conditions that can result in severe damage to the body's tissues.
Healthcare providers should watch out for new and highly contagious forms of ringworm or jock itch, which are emerging as a potential public health threat, according to a pair of reports.
A high sodium diet may increase the risk of eczema, according to researchers, who found that eating just one extra gram of sodium per day increases the likelihood of flares by 22%.
Reaserchers have created a prototype for what they call 'living bioelectronics': a combination of living cells, gel, and electronics that can integrate with living tissue. Tests in mice found that the devices could continuously monitor and improve psoriasis-like symptoms, without irritating skin.
Researchers have developed a fully biobased hair conditioner using lignin gel emulsions, offering a sustainable and environmentally friendly alternative to conventional haircare products.
Workplace bullying affects not only the employee's sleep but their partner's too, according to new research published today.
Researchers used visual threat manipulation in the virtual reality environment and thermal stimulation to investigate how the brain perceives pain. They found that the brain perceives pain more strongly when the perceived pain is out of alignment with reality. In particular, pain was amplified when unexpected events occurred.
Using the microscopic structures found on the wings of the Morpho butterfly, researchers have developed a simple and inexpensive way to analyze cancer biopsy samples that could make cancer diagnosis faster, more accurate and more accessible worldwide.
Sweden's Viking Age population appears to have suffered from severe oral and maxillofacial disease, sinus and ear infections, osteoarthritis, and much more. This is shown in a study in which Viking skulls were examined using modern X-ray techniques.
Researchers have discovered a fundamental mechanism that affects the size of the pupil, namely our breathing. The study shows that the pupil is smallest during inhalation and largest during exhalation -- something that could affect our vision.
A diet of fruits and vegetables, whole grains, low-fat dairy foods and lean meats, low in salt and sugar, is associated with reduced psoriasis severity, new research finds.
Researchers have discovered and analysed a rare but serious side effect of an innovative form of blood cancer therapy.
The combination of prescribed central nervous system stimulants, such as drugs that relieve ADHD symptoms, with prescribed opioid medications is associated with a pattern of escalating opioid intake, a new study has found.
Because almost no existing programs focus specifically on reducing ultra-processed food (UPF) intake, researchers recently designed an intervention that included a variety of tactics to target the uniquely problematic aspects of UPFs. On average, participants successfully reduced their UPF intake by almost half.
Adding engineered human blood vessel-forming cells to islet transplants boosted the survival of the insulin-producing cells and reversed diabetes in a preclinical study. The new approach, which requires further development and testing, could someday enable the much wider use of islet transplants to cure diabetes.
Researchers have pioneered a new catalytic transformation that converts epoxides into fluorinated oxetanes, a coveted but difficult-to-make class of drug molecules that escaped synthetic preparation for years. By unlocking a pathway to these valuable drug scaffolds, this discovery potentially opens the door to new medicines for drug discovery applications.
Infection with Zika virus in pregnancy can lead to neurological disorders, fetal abnormalities and fetal death. Until now, how the virus manages to cross the placenta, which nurtures the developing fetus and forms a strong barrier against microbes and chemicals that could harm the fetus, has not been clear. Researchers now report a strategy Zika virus uses to covertly spread in placental cells, raising little alarm in the immune system.
Researchers have investigated how microbubbles tiny gas bubbles can deliver drugs into cells in a targeted manner using ultrasound. For the first time, they have visualized how tiny cyclic microjets liquid jets generated by microbubbles penetrate the cell membrane enabling the drug uptake.
Seeking mental health help is a significant step, but that first intake session can often feel more like paperwork than progress, and a significant proportion of people 'drop out' or never return for a second visit, previous research has shown. In a new review investigators confirmed that single-session interventions (SSIs) can significantly improve mental health outcomes in both youth and adults. Common in other countries but not the U.S., an SSI is a structured program intentionally designed to provide meaningful support, guidance or treatment in just one meeting, recognizing that many patients may not return for a follow-up appointment.
Researchers developed a low-cost, scalable terahertz amplifier that could be used to make antenna arrays that can steer and focus high-frequency terahertz waves, for applications like high-resolution radar, high-speed communications, and medical imaging.
A robotic device allows eye surgeons to perform high-precision procedures on the retina, the fragile lining on the back of the eye that is less than a millimeter thick.
Fetal acetaminophen exposure increases the likelihood that a child will develop attention-deficit/hyperactivity disorder (ADHD), according to a new study.
A new vaccine that boosts immunity against tuberculosis (TB) has been shown to be effective in pioneering pre-clinical trials.
Researchers have developed Deep Nanometry, an analytical technique combining advanced optical equipment with a noise removal algorithm based on unsupervised deep learning. Deep Nanometry can analyze nanoparticles in medical samples at high speed, making it possible to accurately detect even trace amounts of rare particles. This has proven its potential for detecting extracellular vesicles indicating early signs of colon cancer, and it is hoped that it can be applied to other medical and industrial fields.
Repurposing amlodipine, a commonly used blood pressure medicine, could help manage attention-deficit/ hyperactivity disorder (ADHD) symptoms, according to an international study.
A new study analyzes the disease burden and the risk factors for severity among people who suffer from a condition called cannabinoid hyperemesis syndrome. Researchers say the condition occurs in people who are long-term regular consumers of cannabis and causes nausea, uncontrollable vomiting and excruciating pain in a cyclical pattern that often leads to repeated trips to the hospital.
Epigenetic inhibitors as a promising new antimalarial intervention strategy? A new study identifies an inhibitor of gene regulation that specifically kills the malaria pathogen.
Scientists know that natural disasters have negative health effects on survivors, but long-term observations are lacking. To help fill this gap, a research team has investigated the connection between the degree of housing damage caused by the Great East Japan Earthquake (GEJE) and all-cause mortality. Using long-term observation periods, this research project shows no significant relationship between the degree of house damage and all-cause mortality.
Shared decision-making between clinicians and athletes of all ages who have cardiovascular abnormalities and want to participate in competitive sports is essential, according to a new joint scientific statement.
Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts.
Acid reducing medicines from the group of proton pump inhibitors (PPIs) are best-selling drugs that prevent and alleviate stomach problems. PPIs are activated in the acid-producing cells of the stomach, where they block acid production. Researchers made the surprising discovery that zinc-carrying proteins, which are found in all cells, can also activate PPIs -- without the presence of gastric acid. The result could be a key to understanding the side effects of PPIs.
Scientists developed a new microscope based on Brillouin scattering -- a phenomenon where light interacts with naturally occurring thermal vibrations within materials, from which their mechanical properties can be deduced. This method has since been used for non-invasive and live-imaging applications in biology.
Researchers have developed a powerful computational tool, named iDOMO, to improve the prediction of drug synergy and accelerate the development of combination therapies for complex diseases. The study highlights iDOMO's ability to identify synergistic drug combinations using gene expression data, outperforming existing methods.
A longer paternity leave after the birth of a child can improve the co-parenting relationship between moms and dads in a key way, a new study finds. Researchers found that mothers were less likely to discourage fathers' involvement in parenting if the dads had taken more time off after their child was born.
A little movement could help prevent dementia, even for frail older adults, suggests a new study.
With the goal of informing clinician practice, a new study explores the harms and benefits of continuing and of discontinuing the long-term prescription of opioid medicines to adults with chronic pain.
A new study shows that enhancing activity of a specific component of 'NMDA' receptors normalizes protein synthesis, neural activity and seizure susceptibility in the hippocampus of fragile X lab mice.
In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells, researchers have identified a vulnerability that opens the door to new treatments.
Scientists have identified novel genetic interactions that may contribute to congenital heart disease (CHD), a common birth defect.
International researchers warn that the ongoing mpox outbreak in the Democratic Republic of the Congo (DRC) has the potential to spread across borders more rapidly. The mpox virus has mutated, and the new variant, clade 1b, has become more infectious.
A discovery offers new hope in the battle against pulmonary fibrosis, a debilitating lung condition that progressively makes it harder for patients to breathe. Scientists have pinpointed proteins in immune cells that, when blocked, could significantly reduce lung tissue scarring.
Scientists report results from a promising new approach to treat the rare neurodegenerative disorder.
New research shows almost 90% of people in England would agree to genetic testing to get the most effective medication and reduce the risk of side effects.
New therapeutic 'cocktails' may provide long-lasting relief for treatment-resistant asthma and other immune system inflammatory diseases.
Scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal neighborhood -- known as the tertiary lymphoid structure -- where they become frustratingly dysfunctional when in close contact with tumors.
Clinical research suggests that combining a novel agent called navtemadlin with DNA-damaging chemotherapy for the treatment of glioblastoma, a form of brain cancer, could increase efficacy. Navtemadlin is an MDM2 inhibitor that can help to kill cancer cells by boosting the activity of p53, a protein that controls cell growth and induces cell death in response to DNA damage. In lab experiments, the researchers found that navtemadlin was one of the best drugs at killing glioblastoma cells with intact, non-mutant p53.
A multi-national, multi-institutional study investigators found little natural resistance to a new HIV therapy called lenacapavir in a population of patients in Uganda.
Breast cancer incidence trends in U.S. women under 40 vary by geography and supports incorporating location information with established risk factors into risk prediction, improving the ability to identify groups of younger women at higher risk for early-onset breast cancer.
A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with the same mutation, a rare finding of a direct genetic link to psychosis, report researchers.
Researchers have found a compound in ginger, called furanodienone (FDN), that selectively binds to and regulates a nuclear receptor involved in inflammatory bowel disease (IBD). While researchers have been aware of FDN for decades, they had not determined its functions or targets in the body until now.
Cancer cells work together to source nutrients from their environment -- a cooperative process that was previously overlooked by scientists but may be a promising target for treating cancer.
Researchers have found that a cancer outside the brain makes electrical connections with the nervous system to fuel cancer growth and aid its spread.
The new post-pandemic national hospital occupancy average is 75% -- a full 11 percentage points higher than the pre-pandemic average, largely due to a reduction in staffed hospital beds. This puts the U.S. on track for a severe shortage of hospital beds by 2032 unless action is taken.
Scientists across Africa, America, Asia, Australia, and Europe outline for the first time how Artificial Intelligence (AI) can transform the landscape of infectious disease research and improve pandemic preparedness.
In the face of the alarming number of opioid-related deaths in the U.S., there have been national efforts to increase emergency clinician prescribing of buprenorphine, a medication used to treat opioid use disorder.
Immune therapy has transformed how cancer is treated, but many tumors continue to evade these treatments, thanks to their resemblance to healthy tissue.
New research focuses on diagnostic delays experienced by people with epilepsy, a neurological disorder characterized by unpredictable seizures that affects over 3 million people in the United States and 50 million worldwide.
A new study led by researchers from Oxford Population Health has shown that a range of environmental factors, including lifestyle (smoking and physical activity), and living conditions, have a greater impact on health and premature death than our genes.
Imagine a cancer treatment that precisely targets malignant cells, leaving healthy ones untouched. Consider, also, a cancer treatment that corrects abnormal protein synthesis to produce healthy proteins in patients. These are just two of the many applications of a new study. The innovative approach, called the ICIT mechanism, introduces a novel way to 'switch on' protein synthesis in target cells only, creating healthy proteins to treat illnesses or toxic proteins to kill unwanted cells.
Acting in the right place at the right time is the key to effective medical treatment with minimal side effects. However, this feat remains difficult to achieve. Biologists and chemists have now succeeded in developing a tool that controls the location at which a molecule is activated by a simple pulse of light lasting only a few seconds. Tested on a protein essential for cell division, this system could be applied to other molecules. The potential applications are vast, both in basic research and in improving existing medical treatments, such as those for skin cancer.
Researchers have tested whether intoxicated people can be reliable witnesses when it comes to identifying a suspect's face after a crime is committed.
War study in Ukraine suggests hydrodissection may reduce pain, opioid use in amputees.
Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to facilitate the uptake of glucose through tissues and organs, leading to an increase in blood glucose (chronic hyperglycaemia). Since skeletal muscle is the tissue that uses the most glucose in response to insulin action, it is the most affected tissue by insulin resistance.
One in five older adults gets an infection up to six months after heart surgery, and women are far more likely to develop one, according to recent studies. Black patients also had higher rates of overall infection compared to white patients. Researchers say estimates of postoperative infections are likely vastly underestimated.
| Apr 5 | My Snail Mucin Is Caught in a Trade War Tariffs could upend America’s love affair with Korean skin care. |
| Apr 5 | The Plight of the K-Beauty Devotee Tariffs have come for snail mucin. |
| Apr 5 | The Plight of the K-Beauty Devotee Tariffs have come for snail mucin. |
| Apr 5 | Can Eating More Veggies Prevent You from Going Gray? As you get older, you might spot those first gray hairs sneaking in. It’s normal, but for lots of people it feels like a little reminder that youth is fading. What if you could push back against that with something natural? Scientists have found a... |
| Apr 4 | Apple Nutrition Facts: Calories, Benefits and Easy Recipes for a Healthy Lifestyle Apples are the powerhouse of essential nutrients, vitamins and minerals, which is why it is amongst the most widely recognized and eaten fruits in the... |
| Apr 4 | Beta-Glucans — Nature’s Immune Booster You Need to Know About Did you know a simple compound in foods like oats and mushrooms could supercharge your immune system? These heroes are called beta-glucans — natural substances that help you fight allergies, infections and even serious diseases like cancer. They’r... |
| Apr 4 | How DMSO Eases Cancer’s Hidden Burdens — Chemo, Pain, and Radiation Relief DMSO is a remarkable naturally occurring substance that (provided it's used correctly 1 ) safely and rapidly improves a variety of conditions medicine struggles with — particularly chronic pain. For example, thousands of studies show DMSO treats a... |
| Apr 2 | Precision Medicine for Prostate Cancer (MedPage Today) -- Outranked only by skin cancer, prostate cancer is the second most common cancer in men in the U.S. Although one in every eight American men will be diagnosed with prostate cancer at some point, an individual's risk can vary grea... |
| Apr 2 | Smart skin sensor offers real-time infection detection An international team led by researchers from the Universitat Rovira i Virgili (URV) has developed an innovative piece of equipment in the field of medical technology: an intelligent device capable of monitoring the temperature of the skin continu... |
| Apr 2 | Common photosensitizing drugs increase skin cancer risk, study indicates Some commonly prescribed photosensitizing drugs increase skin cancer risk, according to a study published online March 18 in Photodermatology, Photoimmunology & Photomedicine. |
| Apr 2 | Melatonin Fights Against Skeletal Muscle Damage Caused by 'Diabesity' Obesity-driven muscle deterioration occurs when mitochondria, the energy-producing centers of your cells, stop working properly. Skeletal muscle requires constant energy, but when insulin resistance sets in, mitochondrial function declines and oxi... |
| Apr 2 | By the Numbers — The State of America’s Health Today The modern health care system is failing at its most basic function — preventing disease and promoting health. Chronic illness has become the norm in the Western world, and despite decades of technical advancements, rates of obesity, diabetes, hea... |
| Apr 1 | What hives look like, possible causes and how you can treat them Hives, also known as urticaria, are a skin reaction that can be caused by many different things, like certain foods […] The post What hives look like, possible causes and how you can treat them appeared first on HealthPartners Blog . |
| Apr 1 | Cold Plunge, Anyone? I’m from Michigan so I know what cold is. I now live in Las Vegas — because I know what cold is. All those years digging my car out of the snow has given me freeze-phobia — I try to avoid anything that’s even associated with the cold. I drink hot ... |
| Apr 1 | The Forgotten Wisdom of Nose-to-Tail Eating In today's health-conscious world, lean protein has become a cornerstone of many diets. Fitness enthusiasts, wellness advocates, and everyday consumers alike often prioritize protein intake, typically focusing on lean muscle meats (such as steaks,... |
| Mar 31 | Sjögren’s Disease 101 Sjögren’s (pronounced show-grins) disease is an autoimmune condition that affects the moisture-making glands in the body. The disease can affect the eyes, mouth, nasal passages — even the vagina — and cause extreme dryness and chronic pain among o... |
| Mar 31 | Should You Take Compounded Medications for Menopause? Perimenopause and menopause symptoms can be brutal. Most women and people assigned female at birth (AFAB) experience vasomotor symptoms (VMS) — night sweats and hot flashes — among other symptoms that can disturb your sleep, affect your mood and l... |
| Mar 31 | Weekly Health Quiz: Butyrate Benefits, Vitamin D, and Cellular Health 1 How can you improve your brain health through the gut-brain axis? Increase your consumption of fiber-rich foods to boost butyrate production Butyrate, produced when gut bacteria ferment dietary fiber, acts as a signaling molecule that supports b... |
| Mar 30 | Beyond Vitamin D Production — How Sensible Sun Exposure Supports Overall Health In this featured video from GrassrootsHealth, Dr. Michael Holick, a professor of medicine, physiology and biophysics at the Boston University School of Medicine and a leading vitamin D researcher, provides eye-opening insights on the importance of... |
| Mar 18 | The COVID Mistake No One Talks Enough About Deaths in isolation have been treated as a painful memory, not as a problem that hospitals need to address. |
| Mar 13 | Early Signs of Diabetes: Symptoms and Warnings While most illnesses and diseases come without signs, diabetes is not one of them. There are certain early signs of diabetes that you must recognize... |
| Mar 13 | Anaemia – Various types and their symptoms Red blood cells are the transport system of your body that carries oxygen to all of the tissues. However, if you have anaemia, your body... |
| Mar 12 | Viral Fever: Causes, Symptoms, Treatment and Prevention Almost all of us make the terrible mistake of dismissing fever as nothing. Fever is a term used for the high temperature of the body.... |
| Mar 12 | Fatty Liver: Everything You Need To Know Introduction Fatty liver is the accumulation of fat on the liver. In medical terms, it is known as hepatic steatosis. Our liver often doesn’t have... |
| Mar 11 | His Daughter Was America’s First Measles Death in a Decade A visit with a family in mourning |
| Mar 11 | 7 Best High Protein Foods You Should Never Miss Introduction Whether you’re trying to build muscles or improve general well-being, protein is an essential nutrient that can make all of this happen. Want long... |
| Mar 7 | The Health Official Who Just Might Stand Up to RFK Jr. Marty Makary could have an impossible job as FDA commissioner. |
| Dec 4 | She's a violinist. He's in a rock band. They investigated a medical mystery that led to a new ski... When violinist Ann Marie Simpson Einziger developed a skin condition abroad it led to a rabbit hole of research with her husband, the creation of a new skincare brand and their own unique happily-ever-after. |
| Jan 21 | What are Hyperbaric Oxygen Chambers? Insights from Medical Professionals Hyperbaric oxygen chambers are specialized medical devices designed to administer oxygen at higher than atmospheric pressures. This blog post aims to demystify these chambers by offering insights from medical professionals. We will explore how the... |